In 1926 they published a description of their aesthetic vision together in the form of the manifesto ”Five Points Towards a New Architecture”. In 1928 the duo erected the Villa Savoy, a building on the outskirts of Paris that embodied their aesthetic ideology. The building's distinct design creates a floating effect, almost as if the house were hovering above the ground.

The cousins also formed a creative trio with Charlotte Perriand between 1927 and 1940. The design trio created, among other things, the classic LC4, Chaise Longue and Fauteuil Grand Confort from 1928. These pieces were originally manufactured by Micahel Thonet, until Cassina, which still produces them today, took over the production in 1965. Among Jeanneret's great achievements is the Chandigarh project, which he undertook with Le Corbusier in India. This was an extensive architectural project that Jeanneret continued to pursue on his own after Le Corbusier dropped out. Jeanneret designed many pieces of furniture for the buildings, which today are extremely sought after. These include chairs, desks and bookcases for the government buildings in Chandigarh.

Pierre Jeanneret often found himself in his cousin's shadow. But he played a major role in the collaboration, not least when it came to professionalism and completing projects and assignments. He often stimulated and provoked his cousin's imagination with his own realism, resulting in groundbreaking design and architecture. Often it was Jeanneret who laid the foundations for the designs, which were then completed by Le Corbusier. Pierre Jeanneret played a major role in the ensuring continuity of the studio, often helping with the technical aspects. Today, Jeanneret's products are sold by brands such as Knoll and Cassina.